The importance of ultrapure water for characterizing bacterial signaling molecules by UHPLC-HRMS/MS

Elga July2022V1

Many species of bacteria use quorum sensing to coordinate behaviors, such as biofilm formation, virulence, and antibiotic resistance. Identifying and characterizing the communication molecules associated with this phenomenon is essential to understanding and potentially modulating these processes. Ultra-high performance liquid chromatography (UHPLC), in combination with high-resolution tandem mass spectrometry (HRMS/MS), can be used for this purpose. However, these techniques require a consistent supply of ultrapure water to obtain reliable results. In this application note, we look at how Karine Escoubeyrou and colleagues at the Bio2Mar Technical Analytical Platform at Banyuls-sur-Mer Oceanographic Observatory have used the ELGA PURELABĀ® Option and flex 2 systems to meet their water purification needs.

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