![Ultrapure water essential for direct determination of bisphenol A by HPLC-MS/MS ElgaKnowledgeSharing January2022](https://e6moi7haf6k.cdn.envigeek.com/wp-content/uploads/2022/01/ElgaKnowledgeSharing_January2022-1024x438.jpg?strip=all&lossy=0&quality=85&webp=80&avif=50&ssl=1&fit=1024%2C438)
Bisphenol A (BPA) was widely used in the manufacture of polycarbonate plastics and epoxy resins, and the risks associated with BPA remain highly controversial. As a result, numerous determinations of trace BPA are now carried out, creating the need for robust analytical processes. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) offers extremely high sensitivity for BPA detection, often with a detection limit of below 2 ppt, making it essential to use ultrapure water throughout the analytical process. A range of ELGA® pure water systems have been tested for this application, and offer effective removal of BPA to below the detection limit of HPLC-MS/MS.