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Biomolecular Interaction Study

GE Healthcare Life Sciences

Surface plasmon resonance (SPR) is a phenomenon that allows real-time, label-free detection of biomolecular interactions. The SPR phenomenon is the basis of many technologies that measure adsorption of material onto planar metal surfaces or onto the surface of metal nanoparticles. When an injected sample containing a potential interaction partner binds to molecules immobilized on a sensor surface, the refractive index at the interface between the sensor surface and the solution is altered to a degree proportional to the change in mass at the surface. Data are presented as a sensorgram that traces the association and dissociation of complexes over the entire course of an interaction, with the kinetics revealed by the shape of the binding curve.

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